Correlation of serum cardiac enzymes activities and schizophrenia

Objective To investigate the changes of serum myocardial enzyme in schizophrenia patients spectrum and its clinical significance.Methods 405 patients with schizophrenia hospitalized patients serum myocar-dial enzyme （CK,CK-MB,LDH,α-HBDH level,） on admission and 4 weeks after treatment the serum myocardial enzyme level,analyze its relationship with the disease, and 100 healthy people （ control group） were compared. Results the positive symptoms of schizophrenia patients before treatment,serum CK,CK-MB,LDH,α-HBDH were （1 286.52 ±714.38） U/L,（40.72 ±27.38） U/L,（143.06 ±33.24） U/L,（115.75 ±22.74） U/L,CK,CK-MB were higher than those in the control group （t=10.35,9.29,all P〈0.01）;after 4 weeks of treatment,CK,CK-MB, LDH,α-HBDH were （98.13 ±38.75）U/L,（12.87 ±5.73）U/L,（125.43 ±25.74）U/L,（102.15 ±26.86）U/L, compared with the control group,the differences were not statistically significant（all P〉0.05）.Conclusion Serum myocardial enzyme CK and CK-MB increased level was related with diseasein the patients with acute exacerbation of schizophrenia. Key words: Schizophrenia; Cardiac enzymes