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Changes of Serum IL-6,IL-8 and T-cell Subgroup in Patients with Severe Acute Pancreatitis and Its Clinical Significance

林瑶光, 覃锦耀, 陈远能, Ying Wang, 陆光润

Abstract

目的探讨细胞因子和T细胞亚群在重症急性胰腺炎(severe acute pancreatitis,SAP)中的变化及临床意义.方法应用双抗体夹心ELISA法检测重症急性胰腺炎和轻型急性胰腺炎(mild acute pancreatitis,MAP)及对照组的血清IL-6、IL-8的含量;应用碱性磷酸酶桥联法(APAAP)检测T细胞亚群.结果重症急性胰腺炎发病初期IL-6、IL-8已升高,明显高于轻型急性胰腺炎和对照组(P 0.05),轻型急性胰腺炎的T细胞亚群与对照组间无显著性差异(P>0.05).重症急性胰腺炎治疗好转期IL-6、IL-8与治疗前比有非常显著性差异(P<0.001),加重或恶化者IL-6、IL-8持续上升;好转患者CD+4、CD+8恢复正常,恶化者保持下降.结论 IL-6、IL-8和T细胞亚群的变化,对重症急性胰腺炎的早期诊断、病情判断和预后评估具有重要的应用价值.

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Key concepts: Medicine, Acute pancreatitis, Pancreatitis, Interleukin, Internal medicine, Gastroenterology, Immunology, Cytokine