An analysis of adverse drug reactions in 279 cases

Objective To study the situation and characteristics of adverse drug reactions (ADR)that occurred in our hospital,and promote clinical rational drug use.Methods Collected 279 ADR cases from 2008 to 2010 in our hospital.Used retrospective analysis method to analyze the sex and age distilbution,drug varieties,route of administration,specific clinical manifestations in ADR,ADR level,and ADR prognosis.Results Among these 279 cases,131 cases are male,and 148 cases are female;those who age from 21 to 30 years and who are younger than 10 years old have the highest ADR incidence rate.Most of the 279 ADR cases are induced by intravenous injection,which occupy 68.46%(191 cases).Antimicrobial drugs were the first category of the drugs that cause ADR,which count for 174 cases (62.37%).The main clinical manifestations are the damage of skin and adnexa,which count for 56.99%(159 cases).New and severe ADR have 15 cases.Conclusion Medical workers should strengthen ADR monitoring to avoid or reduce the incidence of ADR,and promote rational clinical drug use. Key words: Adverse drug reaction;  Analysis;  Monitoring;  Rational drug use