Pathological biopsy and clinical analysis of 33 chidren with refractory nephrotic syndrome

Objective To analyze the pathological types and clinical data of children with refractory nephrotic syndrome in Nanyang and provide reliable basis for clinical diagnosis,treatment and prognosis.Methods Thirty-three children with nephrotic syndrome from October 2010 to October 2011 were studied retrospectively,the pathological type,clinical diagnosis,treatment information were compared and analyzed.Results Among the 33 cases,simple nephrotic syndrome in 10cases,nephritis in 23 cases,pathological types of MsPGN accounted for 39.1％,MCD accounted for 17.4％,FSGS and IgAN each accounted for 13.0％,MPGN and MN each accounted for 8.7％.One patient with FSGS and 1 patient with MN request transfer loss,31 cases were given corresponding treatment after pathological types were definited.No serious complications or drug side effects occured.Conclusions Early renal biopsy should be done to children with refractory nephrotic.The most common pathological types of refractory nephrotic syndrome in Nanyang region are MsPGN and MCD,the preferred application was prednisone 2 mg/( kg · d) and cyclophosphamide 8 -12 mg/(kg · d),2 days every time,a total of 6 -8 times. Key words: Refractory nephrotic syndrome; Chidren; Pathological type; Clinical analysis