Significance of Repeat Renal Biopsies in Children with Frequently Relapsing Nephrotic Syndrome

Objective To observe the pathological diversification in children with frequently relapsing and refractory nephrotic syndrome.Methods 30 children with repeat renal biopsies,who exhibited frequently relapsing nephrotic syndrome and had no sensitivity with steroid,were analyzed to study the pathological diversification,clinical manifestation and laboratory examination.Results The interval between biopsies was from 2 months to 67 months,the mean interval was 24.5 months.22 cases were diagnosed as primary nephrotic syndrome,8 cases were secondary nephrotic syndrome.11 cases(36.7%) had a pathological diversification;the times of relapse were from three to nine times,the mean of which was 3.5 times.Conclusion If the curative effects are not satisfactory for children with frequently relapsing and refractory nephrotic syndrome,the therapy method should be adjusted.After a new treatment protocol failed,it is advocated to perform the repeat biopsies early in order to learn the pathological diversification and regulate the treatment protocol in time.