The clinical effects and influence on CA125, endometrial antibody of triptorelin the treatment of patients with endometriosis surgery

Objective To compare the clinical effects and influence on CA125, endometrial antibody of triptorelin the treatment of endometriosis surgery endometriosis surgery, to provide reference for clinical treatment. Methods 60 patients with endometriosis surgery were randomly divided into 30 cases of I group and 30 cases of II group, I group was treated with mifepristone on the first days after menstruation 12.5mg/d,qd,II group was given triptorelin 3.75mg,every 28 days for 1 times, treated for 3 months, the symptoms and signs before and after treatment were observed,then menstruation and dysmenorrhea score were evaluated, Elbow vein blood was taken out for calculating CA125 and serum antiendometrial antibody, the clinical efficacy were evaluated and the adverse reactions were observed, all patients were followed up for 1 years, then 1 years cumulative pregnancy rate were recorded. Results The CA125, EMab, menstrual score, dysmenorrhea score of I group and II group after the treatment were(18.2±2.8)U/m L and(8.8±3.2)U/m L,(405.2±141.1)pg/ m L and(202.1±79.8)pg/m L,(18.85±6.32)score and(7.68±4.19)score,(1.91±0.35)score and(0.95±0.63)score, all index of both group after treatment were significantly lower than those before treatment(t =8.433 and 14.824,7.659 and 14.578,20.772 and 26.286,15.853 and 19.513,P 0.05);〛the irregular vaginal bleeding rate of I group was 23.33%,the II group were 3.33%,χ2=5.192,P< 0.05. Conclusion Triptorelin and mifepristone has same clinical effect in endometriosis postoperative, but triptorelin can reduce more effectively the CA125 and anti endometrium antibody, abnormal vaginal bleeding and reduce dysmenorrhea postoperative, postoperative recurrence rate and pregnancy rate is good, can be used as a recommended drugs in the treatment patients with endometriosis surgery. Key words: Endometriosis; Triptorelin; Mifepristone; Serum CA125; Anti endometrial antibody