Diagnostic and therapeutic efficacy of cold knife conization for cervical intraepithelial neoplasia

Objective To evaluate the diagnostic and therapeutic efficacy of cold knife conization for cervical intraepithelial neoplasia(CIN),their postoperative histoligical findings and clinical outcomes. Methods We retrospectively analyzed 92 patients with cervical intraepithelial neoplasia(CIN),compared the histological findings between cervical conization and colposcopic multiple punch biopsies. Results Of the 92 cases, there was a correlation in histological findings between cervical conization and colposcopic multiple punch biopsies in 68 cases(73.9%), the other 24 cases(26.1%) did not correspond. Incomplete excision occurred in 3 cases(3.3%) of 92 patients with CIN lesion in the cone specimens, but failure rate (persistence or recurrence) was only 1.1%, the cure rate was 98.9%. Two cases of early invasive cancer were detected. Five cases had additional hysterectomy or semi-radical hysterectomy. The main complications associated with conization were haemorrhage and cervical stenosis.Bleeding occurred in 4.3% of our patients, and cervical stenosis occurred in 1.1% of our patients. Conclusions Cervical intraepithelial neoplasia was diagnosed more correctly by conization than multiple punch biopsies.Otherwise conization can play an important therapeutic role for cervical intraepithelial neoplasia and early invasive cancer. Key words: Cervical intraepithelial neoplasia;  Conization;  Biopsy;  Pathology