Diagnostic and therapeutic cold knife conization for cervical intraepithelial neoplasia

Objective:To evaluate the diagnostic and therapeutic efficacy of using cold knife conization for cervical intraepithelial neoplasia (CIN).Methods:The data of 93 cases with CIN diagnosed and treated in our hospital were retrospectively analyzed.The histologic diagnoses from cervical conization and from colposcopic multiple punch biopsies were compared,and then their postoperative histologic findings and clinical outcomes were evaluated.Results:Of the 93 patients,there was a correlation in histologic findings between cervical conization and colposcopic multiple punch biopsies in 69 cases (74.2%),and there was no correlation in the other 24 cases (25.8%).Incomplete excision was performed in 4 cases (4.3%),but the failure rate was only 2.2%;the cure rate was 97.8%.Three cases with early invasive cancer were found.Six patients underwent subsequent hysterectomy.The main complications associated with conization were hemorrhage and cervical stenosis.Bleeding occurred in 5 (5.4%) of the patients,and cervical stenosis occurred in 2 (2.2%).Conclusion:Cervical intraepithelial neoplasia is diagnosed more accurately using conization than by colposcopic multiple punch biopsies.Conization can also play an important role in the treatment for CIN.If properly performed,the procedure will have a low risk of complications.It can provide an accurate histologic representation of the disease process,and it is also curative in most cases.