Therapeutic effect of sivelestat sodium on early lung blast injury in rabbits

Objective To investigate the changes of neutrophil elastase(NE) and the therapeutic effects of sivelestat sodium on early blast lung injury in rabbits. Methods 30 healthy New Zealand rabbits were randomly divided into:group A was the control group; B group was the treatment group(sivelestat sodium).Given the sivelestat sodium 10mg/kg through ear vein injection immediately after injury to treatment group;saline control group,intravenous injection of the same dose.Tumor necrosis factor-α(TNF -α)content and NE activity in plasma were measured before treatment and after injury. Results PO2 of Sivelestat treated group were(89.1±9.7),(90.9±10.5),(101.1±7.0)mm Hg(1 mm Hg= 0.133 kPa)that was significantly higher than the control group[(81.3±8.7),(74.2±7.8),(94.2± 9.8) mm Hg]at 1, 6, 12 three time points(P< 0.05), TNF-αcontent of the treated group(122.8± 13.6),(85.1±12.9),(81.1±7.2)ng/L decreased significantly compared with the control group(151.4 ±12.1),(101.3±10.8),(93.8±10.5)ng/L at 1, 6,12 three time points(P<0.05), NE activity of the treated group(70.5±6.1),(104.8±5.4),(84.5±4.6),(56.3±8.6)ng/L decreased significantly compared with the control group(91.8±6.3),(160.5±9.5),(127.7±8.3),(109.4±7.2)ng/L at all 1, 6, 12, 24 four time points(P<0.05). Conclusion NE activity played an important role in the occurrence and development.Sivelestat sodium can inhibit the activity of plasma NE and inflammatory cytokine release of TNF-α, reduce the infiltration of neutrophils after early blast lung injury. Key words: Blast lung injury; Rabbit; Inflammatory factor; Sivelestat sodium