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Relationship between mannose-binding lectin and macrovascular complications in type 2 diabetes mellitus

Yingfen Qin, Gui-xing Fang, Zuojie Luo, Di-di Huang, Jia Zhou

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Abstract

Serum mannose-binding lectin (MBL) and high sensitivity C-reactive protein (hs-CRP) levels were measured by ELISA in healthy control subjects and type 2 diabetic patients with and without macrovascular complications matched for age,sex,and duration of diabetes.The results showed that serum MBL concentration was significantly lower in type 2 diabetic patients without macrovascular complications than that in patients with macrovascular complications and in healthy control subjects(both P＜0.01),while no significant difference was found between the latter two groups.Hs-CRP level in type 2 diabetic patients was higher than that in control subjects (both P＜0.01),but there was no significant difference between two groups of diabetic patients (P＞0.05). Key words: Diabetes mellitus，type 2; Macrovascular complications; Mannose-binding lectin; High sensitivity C-reactive protein

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What this paper is about

Serum mannose-binding lectin (MBL) and high sensitivity C-reactive protein (hs-CRP) levels were measured by ELISA in healthy control subjects and type 2 diabetic patients with and without macrovascular complications matched for age,sex,and duration of diabetes.The results showed that serum MBL concentration was significantly lower in type 2 diabetic patients without macrovascular complications than that in patients with macrovascular complications and in healthy control subjects(both P＜0.01),while no significant difference was found between the latter two groups.Hs-CRP level in type 2 diabetic patients was higher than that in control subjects (both P＜0.01),but there was no significant difference between two groups of diabetic patients (P＞0.05). Key words: Diabetes mellitus，type 2; Macrovascular complications; Mannose-binding lectin; High sensitivity C-reactive protein

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Available abstract

Serum mannose-binding lectin (MBL) and high sensitivity C-reactive protein (hs-CRP) levels were measured by ELISA in healthy control subjects and type 2 diabetic patients with and without macrovascular complications matched for age,sex,and duration of diabetes.The results showed that serum MBL concentration was significantly lower in type 2 diabetic patients without macrovascular complications than that in patients with macrovascular complications and in healthy control subjects(both P＜0.01),while no significant difference was found between the latter two groups.Hs-CRP level in type 2 diabetic patients was higher than that in control subjects (both P＜0.01),but there was no significant difference between two groups of diabetic patients (P＞0.05). Key words: Diabetes mellitus，type 2; Macrovascular complications; Mannose-binding lectin; High sensitivity C-reactive protein

Key concepts: Internal medicine, Mannan-binding lectin, Diabetes mellitus, Medicine, Endocrinology, Type 2 Diabetes Mellitus, C-reactive protein, Lectin

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Relationship between mannose-binding lectin and macrovascular complications in type 2 diabetes mellitus — Research Paper | ScholarLens