Retrospective review and drug resistance of pathogenic bacteria causing nosocomial infection

Objective To evaluate the distribution and drugs resistance of pathogens causing nosocomiaI infection over 2 recent years in the hospital.Methods A total of 3944 strains of pathogens were analyzed statistically by retrospective study.Results Among 3 944 strains of pathogens,1078 were gramDositive cocci(27.3%)and 2866 were gram-negative bacilli(72.7%).Ovet the 2 years,the detection rates of extended spectrum β-lactamase-producing Escherichia coli and Klebsiella sppl were 36.5%and 27.9%,respectively.The average resistance rate of gram-positive cocci to penicillin,oxacillin,cefazolin,erythromycin,co-trimoxazole and ciprofloxacin over the 2 years were up to 84.5%.The average resistance rate of gram-negative bacilli to ampicillin was 96.0%and to cefotaxime,cefepime,gentamycin,co-trimoxazole, ciprofloxacin and aztreonam were 52.7% in 2 years.Conclusions Over the 2 years,gramnegative bacilliin strains causing hospital nosocomial infections increased,gram-positive cocci strains remam stable.In view of the increasing drug resistance,rational use of antimicrobial agents should be stressed in the clinic. Key words: Nosocomial infection; Gram-positive cocci; Gram-negative bacilli; Antimicrobial agents; Antimicrobial resistance