姜树林, 青雪梅, 孙殿军
Abstract
目的观察砷、氟、黄绿青霉素和T-2毒素对SGC-7901细胞基因组DNA的损伤作用及特点.方法染毒剂量10 μmol/L,染毒后4 h应用单细胞凝胶电泳技术结合彗星图像分析系统检测DNA损伤.结果 NaAsO2组尾长明显大于对照组;NaF组拖尾率显著高于对照组;CIT组总拖尾率、尾长和尾动量均高于对照组;而T-2毒素组各指标均高于对照组.结论 NaAsO2、NaF、CIT和T-2毒素均可引起DNA损伤,但各有特点,说明它们引起DNA损伤的机制可能是不同的.
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目的观察砷、氟、黄绿青霉素和T-2毒素对SGC-7901细胞基因组DNA的损伤作用及特点.方法染毒剂量10 μmol/L,染毒后4 h应用单细胞凝胶电泳技术结合彗星图像分析系统检测DNA损伤.结果 NaAsO2组尾长明显大于对照组;NaF组拖尾率显著高于对照组;CIT组总拖尾率、尾长和尾动量均高于对照组;而T-2毒素组各指标均高于对照组.结论 NaAsO2、NaF、CIT和T-2毒素均可引起DNA损伤,但各有特点,说明它们引起DNA损伤的机制可能是不同的.
Key concepts: Toxin, Chemistry, DNA damage, Molecular biology, DNA, Microbiology, Biology, Biochemistry