Comparative study between 99Tcm-MDP renal dynamic imaging and measurement of serum cystatin C in evaluation of glomerular function

Objective To compare the difference between 99Tcm-diethylenetriaminepentaacetic acid (99Tcm-DTPA) renal dynamic imaging and measurement of serum cystatin C in evaluation of glomerular filtration rate (GFR). Methods One hundred patients were selected at random, 38 cases with hy-pertension, 35with nephrosis, 10 with arteriosclerosis obliterans, 9 with diabetes and 8 with other diseases. Evaluation of patients'GFR was made separately by 99Tcm-DTPA renal dynamic imaging and measurement of serum cystatin C. Results No significant difference of GFR was found between the two methods (t=1.591, P＞0.05 ),and linear correlation was showed as well (r=0.809, P＜0.01 ). The imaging also revealed the function of individaul kidney, renal blood perfusion and excretory function besides GFR. Conclusions Results of GFR from the two methods revealed no significant difference and they were highly correlated. 99Tcm-DTPA renal dynamic imaging could reveal the individual renal function and provide a more comprehensive evaluation of renal function while the measurement of serum cystatin C was simple and convenient, timesaving, economic, and more suit-able for screening patients'renal function clinically. Key words: Glomerular filtration rate; Technetium Tc 99m pentetate; Cystatin C