The Comparative Study of the Measurement of Serum Cystatin C and ~(99m)Tc-DTPA for the Measurement of Glomerular Filtration Rate (GFR) in Type 2 Diabetic Nephropathy

To explore the clinical value between measurement of serum cystatin C(Cys C) and determination of plasma with 99mTc-DTPA glomerular filtration rate(GFR) clearance for type 2 diabetes(T2DM) in early detection of renal damage,the serum cystatin C levels in 87 patients with type 2 diabetes were determined by immune turbidimetry Cys C.The patients were also carried out dynamic imaging to measure renal GFR.The result showed that the serum levels of Cys C in patients with Type 2 diabetic was 1.68 ± 0.52mg / L,the normal group was 0.72±0.26 mg/L;The GFR in patients with T2DM was 93.8 ± 30.2ml/min/1.73m2,the control group was 107.48±15.23 ml/min/1.73m2,there was significant difference between patients and controls(P0.01).There was a negatively correlation between serum Cys C and 99mTc-DTPA renal dynamic imaging.The serum Cys C could reflect the damage in early diabetic patients.The method is simple,accurate and easy to spread.The renal dynamic imaging method of GFR determination is slightly complex and requires specialized equipment.It can reflect the sub-renal function.The combined measurement of serum Cys C and GFR are very important in the early detection of type 2 diabetic patients with early renal function.