2015•Chin J Postgrad MedRequires access
Expression of Survivin in colorectal cancer tissue and its relationship with clinicopathological features
Jun Xue, Xueliang Wu, Fei Guo, Likun Wang, Pengjuan Zhang, Ming Qu
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Abstract
Objective
To explore the expression of Survivin in colorectal cancer tissue and its relationship with clinicopathological features.
Methods
In situ hybridization was used to examine the expression of Survivin mRNA, and immunohistochemical method was used to detect the expression of Survivin protein in 60 cases of colorectal cancer and 30 cases of colorectal normal mucos tissue. The relationship of the expression of Survivin protein with clinicopathological features of colorectal cancer was analyzed.
Results
The positive expression rate of Survivin protein in colorectal normal mucos tissue (10.00%, 3/30) was lower than that in colorectal cancer tissue (73.33%,44/60), and there was significant difference (P 0.05).
Conclusions
The specific high expression of Survivin protein has a high correlation with the occurrence, development, infiltration of colorectal cancer. Survivin may be used as a marker for prognosis of patients with colorectal cancer.
Key words:
Colorectal neoplasms; Immunohistochemistry; In situ hybridization; Survivin