Relationship Between the AGT Gene and AT1R Gene Polymorphisms and Cerebral Infarction

Objective:To identify an interaction between angiotensinogen(AGT) gene polymorphisms and angiotensin Ⅱ type Ⅰ receptor(AT1 R) gene polymorphisms on the risk of cerebral infarction.Methods: AGT genotypes and AT1R genotypes were investigated with the methods of PCR-RLFP in 77 patients with cerebral infarction(CI) and 98 healthy individuals controls.Fatalness of genetic factors toward CI were analyzed by Logistic regression.Results: AGT T704C gene polymorphism revealed significant difference of CC genotype and C allelic distribution in CI patients(63.6%,79.9%) and controls(34.7%,61.2%).There were significantly difference in the frequencies of AT1R A1166C genotypes and C allele among CI patients(61.1%,30.5%) and controls(8.2%,4.1%);Logistic regression analysis showed the polymorphsim of AGT gene was therisk factor for cerebral infarction(OR=2.513,P0.05);the polymorphsim of AT1R gene was the risk factor for cerebral infarction(OR=10.322,P0.05).The polymorphsim of AGT gene and AT1R allele might have coordinating function in the pathogenesis of cerebral infarction(OR=14.325,P0.05).Conclusion:The polymorphism of AGT is related to the incidence of CI;There were synergistic effects of AGT and AT1R gene polymorphisms on the risk of CI.