Effects of sequential non-invaslve following short-term invasive mechanical yentilation in chronic obstructive pulmonary disease patients with respiratory failure

Objective To research the method and effect of sequential non-invasive following shortterm invasive mechanical ventilation in chronic obstractive pulmonary disease (COPD) patients with rcepiratory failure.Methods 41 COPD patients with respiratory failure were divided into experiment group (n=21) and control group (n=20) randomly.At the time of pulmonary infection control(PIC) window,patients of experiment group were extubated and treated by non-invasive mechanical ventilation,then patients of control group were kept treating by invaaive mechanical ventilation and weaned by PSV mode.The duration of invaaive mechanical ventilation、total invasive mechanical ventilation、ICU and hospital stay,the VAP and death in hospital were compared between two groups.Results:After treatment,the invasive mechanical ventilation time,total mechanical ventilation time,ICU and hospital stay were shorterand the incidence of VAP was lower(P＜0.05) as compared with the control group.Conclusion Sequential non-invasive following invasive mechanical ventilation at the PIC window is a may significantly decrease the invasive and total durations of ventilatory support,duration of ICU and hospital stay,the risk of VAP,and the cost of therapy,also increasing the efect of therapy. Key words: Chronic obstructive pulmonary disease (COPD); Respiratory failure; Sequential mechanical ventilation