Sequential non-invasive following short-term invasive mechanical ventilation in COPD patients with severe respiratory failure

Objective To evaluate the efficacy of sequential non-invasive following short-term invasive mechanical ventilation in COPD patients with severe respiratory failure. Methods Forty COPD patients with severe respiratory fai-lure were studied.When pulmonary infection had been controlled,20 patients(treatment group)were extubated and treated by non-invasive mechanical ventilation,20 cases(control group)were kept treating by invasive mechanical ventilation and weaned by PSV mode.The duration of invasive mechanical ventilation,total mechanical ventilaiton,hospitalization and care,the incidence of ventilator-associated pneumonia(VAP) were compared between two groups. Results For treatment group and control group,the incidence of VAP was 5%(1 case) vs 40%(8 cases)(P0.05),the total duration of mechanical ventilation was 10.4±2.5 d vs 15.3±3.2 d(P0.05) and the duration of hospitalization was 16.2±2.8 d vs 25.8±4.2 d(P0.01) respectively. Conclusions Sequential non-invasive following invasive mechanical ventilation at the time of pulmonary infection control(PIC) window may significantly shorten the duration of mechanical ventilation and hospitalization,reduce medical expense and the frequency of VAP,and enhance the rescue success rate.