2016•药物不良反应杂志Requires access
Thrombocytopenia and hypofibrinogenemia induced by sodium valproate
Chenyu Guo, Wenwen Zheng, Kaimin Li, Congxiao Lu
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Abstract
A 58-year-old male received a continuous intravenous fusion of sodium valproate 33.6 mg/h for 3 days because of epileptic seizure. Seven days later the patient underwent the the excision of lesion of left temporal lobe. The day after operation his platelet count (PLT) decreased from 242×109/L which was tested on hospitalization to 100×109/L, but he did not receive any treatment for the decreasing PLT. He received the continuous intravenous infusion of sodium valproate according to the primary dose again for 4 days. His PLT decreased to 72×109/L, prothrombin time (PT) prolonged to 20.7s from 13.4 s, and fibrinogen (FIB) decreased from 2.08 to 0.99 g/L. The patient was diagnosed as thrombocytopenia and hypofibrinogenemia induced by sodium valproate. Sodium valproate was withdrawn and cryoprecipitate 6.0 U was given. One week after drug withdrawal the laboratory tests showed the following values: PLT 294×109/L, PT 13.2 s, and FIB 2.57 g/L.
Key words:
Valproic acid; Thrombocytopenia; Afibrinogenemia