2017•药物不良反应杂志Requires access
Three lineage pancytopenia induced by preventive and over course treatment of sodium valproate
Hua Ni, Yong Yuan, Hui Liu, Wenjing Ni
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Abstract
A 56-year-old male patient received sodium valproate 0.5 g/d for prevention of epilepsy because of postoperative cerebral hemorrhage. Thirty-six days later, the results of reexamination showed the following values: white blood cell (WBC) 3.3×109/L, red blood cell (RBC) 3.2×1012/L, hemoglobin (Hb) 100 g/L, platelet count (PLT) 94×109/L. He did not receive any treatments and continued to take sodium valproate at the same dose. One hundred and two days later, the results of reexamination showed the following values: WBC 1.9×109/L, RBC 3.2×1012/L, Hb 90 g/L, PLT 82×109/L. He was diagnosed with 3 lineage pancytopenia. Sodium valproate was withdrawn. The results of reexamination 13 days later showed the following values: WBC 4.3×109/L, RBC 3.5×1012/L, Hb 100 g/L, PLT 109×109/L.
Key words:
Valproic acid; Pancytopenia