The Research on the Relationship Between Serum High-Sensitivity C-Reactive Protein and Interleukin-6 in Acute Coronary Syndrome Patients

Objective To investigate the relationship among the inflammatory markers of high-sensitivity Creactive protein(hs-CRP), interleukin-6 (IL-6) and the process of the acute coronary syndrome (ACS).Methods Immunity turbidimetry assay was used to test the serum hs-CRP,and enzyme linked immunosorbent assay (ELISA) was used to test the serum IL-6 in 60 ACS cases[33 cases with acute myocardial infarction(AMI) ,27 cases with unstable angina pectoris(UAP)],45 cases with stable angina pectoris (SAP)and 45 healthy persons. The differences of the serum hs-CRP and the serum IL-6 were compared among the three groups and the correlation between serum hs-CRP and the serum IL-6 was also analyzed in the ACSs. Results The concentrations of the serum hs-CRP and the serum IL-6 in ACSs were both significantly higher than those of SAPs and healthy persons (all P＜0.01).The concentrations of the serum hs-CRP and the serum IL-6 in AMIs were significantly higher than those of UAPs (all P＜0.05). And there was a direct correlation between the serum hs-CRP and the serum IL-6 in ACSs (r=0.836).Conclusion The levels of the serum hs-CRP and the serum IL-6 could be used to judge the stability of the plaques,and there was some direct correlation between them in the ACS process, and they should he valuable to predict the prognosis of ACSs. Key words: Acute coronary syndrome;  High-sensitivity C-reactive protein;  Interleukin-6;  Correlation