Correlation of Level and the Prognosis of Serum S100β Protein and High Sensitive C-reactive Protein in Acute Cerebral Infarction

Objective To study the changes of the levels of serum S100β protein and high sensitive C-reactive protein(hs-CRP) in acute cerebral infarction patients and their clinical significance.Methods To adopt the concentration of serum S100β protein was detected using double antibody sandwich ELISA;and using the serum high sensitive C-reactive protein levels were measured in 33 cases with acute cerebral infarction patients and 25 normal control were measured.healthy people who received medical examinations.A analyzed the relationship between the serum S100β protein and high sensitive C-reactive protein levels and the severity of disease as well as outcome.The changes of S100β and hs-CRP were compared with patients of different pathogenetic condition and infarction areas.The correlation analysis between S100β and hs-CRP was also made.Results The level of serum S100β(0.025±0.017 μg/L) and hs-CRP(7.147±10.503 mg/L) in patients with ACI increased significantly compared with control group(0.017±0.009 μg /L,2.679±1.678 mg/L)(all P0.05).The level of serum S100β protein and hs-CRP increased with the neurofunction detection and infarction area.The level of serum S100β has positive correlation with the level of hs-CRP.Conclusion The levels of the serum S100β protein and hs-CRP remarkably increase in the patients with ACI.The serum of S100β protein and hs-CRP not only provides quantitative information about the degree of certain neurologic lesions,but also serves as an important parameter of assessing the prognosis.