The clinical significance of the serum levels of hs-CRP and IL-6 in patients with acute cerebral infarction

Objective To investigate the clinical significance of the serum levels of hs-CRP and IL-6 in patients with acute cerebral infarction(ACI). Methods 90 patients with ACI were selected and divided into different groups according to the size of infarction and clinical neurologic impairment degree score. The serum hs-CRP level was detected by immunoturbidimetry, IL-6 concentration was detected by enzyme-linked immunosorbent assay (ELISA).Results The serum hs-CRP and IL-6 levels in the patients with ACI were significantly higher than that in the healthy subjects ( P ＜ 0.05). Comparing groups with the different infarction size: the serum levels of hs-CRP and IL-6 were increased steply with the volume of infarction,the differences between the groups were significant( all P ＜0.05). Comparing the three groups : the serum levels of hs-CRP and IL-6 were increased steply with the clinical neurologic impairment degree score ,the differences between the groups were significant( all P ＜ 0.05 ). Conclusion The serum levels of hs-CRP and IL-6 were significantly elevated in the patients with ACI. The serum levels of hs-CRP and IL-6 were increased closely with the volume of infarction and the clinical neurologic impairment degree score, which suggests that hs-CRP and IL-6 should play an important role in the pathogencsis of ACI, and probably be a prognostic factor of ACI. Key words: Acute cerebral infarction;  C-reactive protein;  Interleukin-6 ( IL- 6) ;  Enzyme-linked immunosorbent assay