Correlation analysis between blood typing test, irregular antibody screening of pregnant women and hemolytic disease of newborn

Objective To analyze the correlation between the blood typing test, irregular antibodies screening of pregnant women and hemolytic disease of newborn(HDN). Methods The ABO blood type and Rh(D) blood type of pregnant women were detected, and the irregular antibodies of pregnant women were screened.The blood type serology and hemolytic disease were detected in neonates with jaundice. Results In specimens of 2 032 pregnant women with type O blood, their husbands were non-O blood type, after delivery, 152 neonates were diagnosed as HDN.Among 2 032 pregnant women with type non-O blood, only 5 neonates were diagnosed as HDN.There was significant difference between the two groups (χ2=135.4, P<0.01).27 pregnant women with RhD negative type, their husbands were RhD positive, after delivery, 4 neonates were diagnosed as HDN. Conclusion Pregnant women's blood type and irregular antibody are closely related to neonatal hemolysis disease.So pregnant women's blood type and irregular antibody should be regular project in pregnancy, and so as to prevent neonatal hemolytic anemia caused by blood type of feto-maternal incompatibility. Key words: Blood type; Irregular antibody; Neonatal hemolysis disease