Comparison of remifentanil and sufentanil on hemodynamics, recovery and cognitive function in patients undergoing laparoscopic cholecystectomy

Objective To compare the effects of remifentanil and sufentanil on hemodynamics, recovery and cognitive function in patients undergoing laparoscopic cholecystectomy. Methods A total of 136 patients undergoing laparoscopic cholecystectomy in Second People′s Hospital of Fuyang District of Hangzhou from March 2013 to March 2018 were collected and divided into two groups, with 68 patients in each group. The remifentanil group was given conventional anesthesia induction and remifentanil anesthesia maintenance, while the sufentanil group was given conventional anesthesia induction and sufentanil anesthesia maintenance. The levels of hemodynamics, awakening, cognitive function and complications of the two groups were compared. Results The levels of hemodynamics (heart rate, systolic blood pressure, diastolic blood pressure) in sufentanil group was stable than those in remifentanil group. Compared with the remifentanil group, the respiratory recovery time, eye opening time and extubation time of sufentanil group were all increased [(10.01 ± 1.25) min vs. (8.17 ± 0.82) min, (10.27 ± 1.39) min vs. (8.05 ± 0.72) min, (14.65 ± 1.51) min vs. (11.08 ± 1.03) min] (P<0.05). In addition, the scores of mini mental state examination (MMSE) on the 1st day after operation in both groups were lower than those on the 3rd day before and after operation, and the scores in remifentanil group were significantly lower than those in sufentanil group, and the scores of sufentanil group were significantly higher on the 1st day after operation [(21.04 ± 2.02) scores vs. (25.08 ± 2.31) scores] (P< 0.05). The incidence of abdominal distension, nausea and vomiting in sufentanil group was significantly lower than those in remifentanil group [2.94%(2/68) vs. 13.24%(9/68), 5.88%(4/68) vs. 26.47%(18/68)] (P<0.05). Conclusions Compared with remifentanil group, sufentanil group has less influence on hemodynamics, faster recovery of cognitive function and less incidence of adverse reactions in patients undergoing laparoscopic cholecystectomy. Key words: Cholecystectomy, laparoscopes; Hemodynamics; Remifentanil; Sufentanil; Anesthesia