Application of Misoprostol Before Artificial Abortion for the Early Pregnancy

Objective To evaluate the feasibility, safety and efficacy of applying Misoprostol before artificial abortion for early pregnancy (≤42 days). Methods From January to June, 2008, 300 early pregnant women who choose artificial abortion were randomly and evenly divided into 3 groups. Group A (n=100) took Misoprostol 400 μg orally and group B were placed Misoprostol 400 μg transvaginally two hours before operation. Group C (control group, n=100) did not take Misoprostol. Informed consent was obtained from all participates. The incidence rate of adverse reactions and post-operative cervical adhesion, effects of cervical dilatation, bleed volume during operation, operative duration were compared between three groups. Results The incidence rate of adverse reactions of group B was significantly lower than that of group A(P 0.05), however, there had significant difference between group A, B and group C (P<0.01). Conclusion Oral misoprostol 400 μg and vaginal misoprostol 400 μg could be a route administration applying for softening the cervix and facilitating cervix dilatation in artificial abortion of early pregnancy women. We recommend vaginal misoprostol because of less incidence rate of adverse reactions. Key words: misoprostol; early pregnancy; artificial abortion; oral misoprostol; vaginal misoprostol