Application of misoprostol in artificial abortion

Objective:To discuss the feasibility,safety and effectiveness of application of misoprostol in artificial abortion.Methods:240 cases of artificial abortion in the outpatient department of gynecology and obstetrics in our hospital were randomly divided into the oral misoprostol group(group A,n=80),the vaginal putting misoprostol group(group B,n=80) and the non-used misoprostol group(group C,n=80).Group A took oral misoprostol 400 μg in preoperative 2h;group B used misoprostol 400 μg in vagina before surgery;group C did not use any drugs.To observe and compare the incidence of adverse reactions,effects of cervical dilatation,blood loss,operative time and postoperative incidence of cervical adhesions in group A and group B.Results:The incidence of adverse drug reactions in group B was lower than that in group A.The difference between two groups was significant(P0.01).In group A and group B,the cervical dilatation effects,blood loss,operative time and postoperative incidence of cervical adhesion had no significant difference(P 0.05),but the difference was significant compared with group C.Conclusion:Oral and vaginal putting misoprostol are the medication methods before artificial abortion operation,but vaginal administration with less adverse reactions is recommeded(P0.01).