Application of Misoprostol Before Artificial Abortion for the Early Pregnancy

Objective To evaluate the feasibility,safety and efficacy of applying Misoprostol before artificial abortion for early pregnancy(≤42 days).Methods From January to June,2008,300 early pregnant women who choose artificial abortion were randomly and evenly divided into 3 groups.Group A(n=100) took Misoprostol 400 μg orally and group B were placed Misoprostol 400 μg transvaginally two hours before operation.Group C(control group,n=100) did not take Misoprostol.Informed consent was obtained from all participates.The incidence rate of adverse reactions and post-operative cervical adhesion,effects of cervical dilatation,bleed volume during operation,operative duration were compared between three groups.Results The incidence rate of adverse reactions of group B was significantly lower than that of group A(P0.01).There were no significant differences in the effects of cervical dilatation,bleed volume in operation,operative duration,and incidence rate of operative cervical adhesion between group A and B(P0.05),however,there had significant difference between group A,B and group C(P0.01).Conclusion Oral misoprostol 400 μg and vaginal misoprostol 400 μg could be a route administration applying for softening the cervix and facilitating cervix dilatation in artificial abortion of early pregnancy women.We recommend vaginal misoprostol because of less incidence rate of adverse reactions.