Relationship between serum C-reactive protein and insulin resistance in patients with type 2 diabetes complicatecl with non-alcoholic fatty liver

Objective To investigate the relationship between serum C-reactive and insulin resistance in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver.Methods Thirty cases of type 2 diabetic patients complicated with NAFLD,32 cases of type 2 diabetic patients and 25 cases of healthy volunteers were choosed.Fasting insulin levels (FINS),glucose and high sensitivity C reactive protein(CRP) were measured.At the same time,body weight index (BMI),the waist hip ratio (WHR) were also calculated.The index of IR was calculated according to the HOMA method.Results Compared with the non-fatty liver group,the average levels of TG,LDL-C,FINS,HOMA-IR,BMI and WHR were significantly higher in fatty liver group (P ＜ 0.05 ).There was no significant difference in blood glucose level between the two groups (P ＞ 0.05).Conclusions T2DM patients complicated with NAFLD have more serious IR,dyslipidemia and obesity; Amelioration of lip metabolism in liver and mitigation of inflammation may help to reduce the extent of IR. Key words: Non -alcoholic fatty liver;  C-reactive protein;  Type 2 diabetes;  Insulin resistance