The study of relationship between insulin resistance and dyslipidemia in type 2 diabetes associated with nonalcoholic fatty liver

Objective To study the relationship between insulin resistance(IR) and dyslipidemia and nonalcoholic fatty liver disease(NAFLD) in type 2 diabetes mellitus(T2DM).Methods Seventy-two patients were divided into fatty liver group and non-fatty liver group.Blood lipid,blood glucose(BG),blood pressure,fasting and 2-hour serum insulin were measured.At the same time,HOMA-IR,body weight index(BMI),the waist hip ratio(WHR) were calculated.the diagnosis of the fatty liver was learned from the check according to an image.Results Compared with the non-fatty liver group,the average levels of TG,LDL-C,FIns,2hIns,HOMA-IR,BMI,WHR,alanine aminotransferase(ALT),γ-glutamyl transpeptidase(γ-GT),uric acid and diastolic pressure were significantly higher in fatty liver group(P0.05～0.01).Furthermore,the levels of high-density lipoprotein(HDL) obviously decreased in fatty liver group(P0.05).Levels of BG and A_(1C) were not significantly different between the two groups(P0.05).Conclusion Compared with the non-fatty liver patients,T2DM patients complicated with NAFLD have more serious IR,dyslipidemia and obesity.It indicates that IR has a significant influence on the outbreak of the fatty liver;The NAFLD is probably one of components of metabolic syndrome.