2017•国际医药卫生导报Requires access
The expression and clinical significance of serum ferritin and T lymphocyte subsets in children with acute leukemia
Yan Li, Jun-Shan Liu
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Abstract
Objective
To investigate the expression and clinical significance of serum ferritin and T lymphocyte subsets in patients with acute leukemia.
Methods
68 children with acute leukemia in our hospital from January 2014 to December 2015 were divided into first diagnosed group (32 cases), stable group (20 cases), and recurrence group (16 cases) according to the different stages of the course of disease, and 30 healthy children were set as control group. Compared the differences of serum ferritin and T lymphocyte subsets in each group, and analyzed the clinical significance.
Results
The level of serum ferritin of first diagnosed group, stable group, and recurrence group were (645.7±78.2)μg/L, (394.8±73.9)μg/L, (682.7±101.7)μg/L, significantly higher than (122.2±26.3)μg/L of control group, and that of first diagnosed group and recurrence group were significantly higher than that of stable group (P<0.05). The levels of CD3+, CD4+, and CD4+/CD8+ of children with acute leukemia were significantly lower than those of control group, and those of stable group were significantly higher than those of first diagnosed group and recurrence group (P<0.05).
Conclusion
Serum ferritin and T lymphocyte subsets have specific guiding significance on clinical diagnosis and condition assessment in children with acute leukemia, with clinical application value.
Key words:
Ferritin; T lymphocyte subsets; Acute leukemia; Expression level; Clinical significance