Effect of early enteral nutrition for severe acute pancreatitis patiens on serum C-reactive protein and T lymphocyte subsets

Objective To study the effect of early enteral nutrition(EEN) for severe acute pancreatitis(SAP) patients on serum C-reactive protein(CRP) and T lymphocyte subsets.Methods Forty-five SAP patients were randomly divided into the experimental group(22 cases) and the control group(23 cases).The experimental group was treated with EEN.The control group were treated with early parenteral nutrition(PN),and EN was given after gastrointestinal function restored(usually after admission 5 to 7 d).On the day 1,5,7 and 11 after admission,the patients of two groups were tested serum CRP and T lymphocyte subsets(CD3,CD4+,CD4+/CD8+ ratio).Results Three patients were excluded experiment,and the other 42 cases were cured.The average hospitalization days and costs in experimental group were lower than that in control group(P0.05).The serum levels of CRP and T lymphocyte subsets,on the first day,were not statistically significant differences between two groups(P0.05).On the 5th,7th and 11th hospitalization day,the serum CRP level was lower in experimental group than that in control group(P0.05),and the T lymphocyte subsets(CD3,CD4+,CD4+/CD8+ ratio) levels were higher in experimental group than those in control group(P0.05).Conclusion This experiment shows that,by comparing experimental group with control group,the treatment for SAP patients with EEN is better in reducing inflammation on the acute reaction period and better in improving immune function.