The diagnostic value of detecting serum cytokeratin 19 fragmen 21-1 combined with squamous cell carcinoma antigen in nasopharyngeal carcinoma

Objective To explore the value of detecting serum cytokeratin 19 fragmen 21-1 (CYFRA21-1) and squamous cell carcinoma antigen (SCCAg) in the diagnosis of patients with nasopharyngeal carcinoma. Methods 79 patients with nasopharyngeal carcinoma from October 2013 to October 2015 as case group and 145 patients with nasopharyngeal chronic inflammation as control group were collected. The CYFRA21-1 level was detected by the electrochemical luminescence immunoassay and the SCCAg level was detected by the enzymoimmunoassay. Comparisons of diagnostic value of CYFRA21-1 and SCCAg to nasopharyngeal carcinoma were conducted according to pathological diagnosis. Results The serum CYFRA21-1 and SCCAg levels in case group were (12.37±1.65) g/L and (1.65±0.37) ng/ml, and the control group were (4.26±1.99) g/L and (1.22± 0.45) ng/ml, with statistically significant differences (t = 8.093, P= 0.002; t = 4.287, P= 0.043). The sensitivity, specificity,positive predictive value, negative predictive value and accuracy of CYFRA21 -1 combined with SCCAg in the diagnosis of nasopharyngeal carcinoma were higher than those of CYFRA21 -1 and SCCAg respectively, and the difference all were statistically significant (all P < 0.05). Conclusion Detecting serum CYFRA21-1 combined with SCCAg in the diagnosis of nasopharyngeal carcinoma has high sensitivity and good specificity, which can significantly improve the diagnostic accuracy. Key words: Nasopharyngeal neoplasms; Cytokeratin 19 fragmen 21-1; Squamous cell carcinoma antigen; Diagnosis