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CLINICAL EVALUATION OF MICROPARTICLE ENZYME IMMUNOASSAY FOR SQUAMOUS CELL CARCINOMA ANTIGEN(SccAg) IN NASOPHARGNGEAL CARCINOMA.

LI Jian-r

Abstract

Objective:To evaluate the significance of microparticle enzyme immunoassay(MEIA) for determinating of squamous cell asscoiated antigen(SccAg) in patients with nasopharyngeal carcinoma(NPC).Methods:Serum SccAg level is in NPC patients was determined by MEIA,and their diagnostic sensitivity,specificity and predictive values for NPC were also analyzed.Patients with benign nasopharyngeal diseases were used as control.Rusults:Levels of serum SccAg between Nasopharyngeal squamous cell carcinoma and nasophatyngeal non-squamous cell carcinoma were not significant,and comparable to those in controls.The sensitivity,specificity,positive predicative value and negative predicative value of serum SccAg for NPC were 6.41%,100%,100% and 60.75%,respectively.Conclusions:Serum SccAg is not a good index for NPC.Serum SccAg detection can not be used to defficiate nasopharyngeal squamous cell carcinoma and nasopharyngeal non-squamous cell carcinoma,but it can be used as an assistant index to differentiate nasopharyngeal benign and nign diseases.

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Key concepts: Nasopharyngeal carcinoma, Medicine, Immunoassay, Predicative expression, Oncology, Antigen, Basal cell, Internal medicine