2014•Central Plains Medical JournalRequires access
Evaluation value of plasma NT-pro BNP concentration on coronary artery lesion and heart function in patients with acute coronary syndrome
马素霞
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Abstract
Objective To investigate the evaluation value of plasma NT-pro BNP concentration on coronary artery lesion and heart function in patients with acute coronary syndrome（ ACS）. Methods The plasma NT-pro BNP and left ventricular ejection fraction（ LVEF）100 ACS patients who were admitted in ICU and 50 healthy persons were detected, and the number of diseased coronary arteries and coronary angiography Gensini score were measured by syntax score assay. Results Compared with health controls,plasma NT-pro BNP levels and Gensini score were significantly higher,LVEF was significantly lower in ACS patients,and with the severity aggravating of ACS and number of diseased coronary arteries, BNP levels and Gensini scores were increased,LVEF was decreased（ P﹤0. 05 ）. There was significant positive relation between plasma NT-pro BNP and number of diseased coronary arteries and Gensini score（r=0. 711,0. 835,P﹥0. 05）, while negative relation was found with LVEF（r= -0. 415,P﹤0. 05）. Conclusions Plasma NT-pro BNP is correlated with coronary artery lesion and heart function in ACS patients. Plasma BNP level increased in patients with sepsis,and it plays a significant role in the early diagnosis and treatment and the risk stratification of ACS.
Key words:
Acute coronary syndrome; Plasma NT-pro BNP; Coronary artery lesion; Heart function