Plasma level of B-type natriuretic peptide in patients with acute coronary syndrome and its clinical significance

Objective To explore the significance of plasma B-type natriuretic peptide(BNP) level in patients with acute coronary syndrome(ACS). Methods Thirty-five patients with ACS and twenty healthy controls were selected into this protocol.Blood samples of ACS patients were extracted from femoral vein on admission immediately and at 24 h after percutaneous coronary intervention(PCI).The plasma BNP was measured by a bedside rapid assay. The plasma level of BNP was compared among those before and after PCI in ACS patients and healthy controls with different conditions of heart function.The relationship of BNP and Gensini scores was studied by correlation analysis.Results The plasma level of BNP was significantly increased in patients with ACS compared with that in the control subjects(P(0.001)),but BNP level was decreased after PCI(P=0.027).Plasma BNP was significantly increased in ACS patients with a LVEF50% than in those with a LVEF≥50%(P0.001),and it was negatively correlated with LVEF(r=(-0.88),P0.001),but there was no significant relationship between Gensini scores and the plasma BNP in ACS group(r=(0.12,) P0.05).Conclusion Plasma level of BNP increased significantly in ACS patients is correlated with classification of heart function,which can be decreased by percutaneous coronary intervention.