Efficacy of oral montelukast combined with budesonide suspension inhalation in the treatment of children with cough variant asthma and its effect on inflammatory cytokines

Objective To investigate the effect of montelukast combined with budesonide suspension inhalation in the treatment of children with cough variant asthma(CVA), and its effect on inflammatory cytokines. Methods 96 patients with CVA were selected, and they were randomly divided into observation group(n=48) and control group(n=48) according to the digital table.The control group was treated with routine western medicine only. On the basis of the control group, the observation group was treated with aerosol inhalation of budesonide suspension and montelukast sodium tablets. The children in the two groups were treated for 3 months, then the treatment effect was evaluated. Results The total effective rate in the observation group was 95.8%, which was significantly higher than 77.1% in the control group(χ2=4.914, P 0.05). After treatment, the levels of IL-8, IL-6 and TNF-α in the two groups were significantly lower than before treatment(t=2.09, 3.13, 2.97, all P 0.05). There were no serious adverse reactions in the treatment group, and the treatment cycle was completed successfully. Conclusion Montelukast combined with budesonide suspension inhalation in the treatment of children with CVA can significantly improve pulmonary ventilation function, reduce cough symptoms, it is safe and effective, which is worthy of clinical reference. Key words: Montelukast; Budesonide suspension; Asthma; Chemokines