2017•国际医药卫生导报Requires access
Changes of the parameters of hydrogen breath test and secretion levels of gastrointestinal hormones in patients with irritable bowel syndrome before and after treatment
Shen Li-min
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Abstract
Objective
To explore the changes of the parameters of hydrogen breath test and secretion levels of gastrointestinal hormones in patients with irritable bowel syndrome (IBS) before and after treatment.
Methods
The hydrogen breath test was performed to determine oro-cecal transit time (OTCC) and the concentration of produced H2 in the normal control group and patients with IBS. Meanwhile, radioimmunoassay was used to detect the contents of plasma motilin (MTL), vasoactive intestinal peptide (VIP), cholecystokinin (CCK), and somatostatin (SS) in normal control group and patients with IBS.
Results
Before treatment, OCTT in patients with diarrhea was significantly lower than those in the normal group and patients with constipation, OCTT in patients with constipation was significantly higher than that in the normal group (P<0.05). Before treatment, the concentration of H2 and the positive rate of SIBO in patients with IBS were significantly higher than those in the normal group, the concentration of H2 and the positive rate of SIBO significantly decreased after treatment (P<0.05). Before treatment, the concentrations of plasma MTL and CCK in patients with diarrhea were significantly higher than those in normal group and patients with constipation, the concentrations of plasma MTL and CCK in patients with diarrhea significantly decreased after treatment, while those in patients with constipation significantly increased (P<0.05). Before treatment, the concentrations of VIP and SS in patients with IBS were significantly higher than those in normal group, the concentrations of VIP and SS in patients with IBS significantly decreased after treatment (P<0.05).
Conclusion
The changes of the parameters of hydrogen breath test and secretion of gastrointestinal hormones are closely related to the pathogenesis of IBS.
Key words:
Irritable bowel syndrome; Hydrogen breath test; Gastrointestinal hormone; Pathogenesis