Correlations between anorectal pressure and plasma gastrointestinal hormones in irritable bowel syndrome

Objective To investigate the role of anorectal presure and plasma gastrointestinal hormones abnormality in irritable bowel syndrome (IBS)and the relationship between them. Methods 43 patients with IBS and 20 healthy subjects were comparatively investigated. Anorectal pressure was measured with anorectal catheta of solid state manometric transducers. Gastrointestinal hormones in plasma including gastrin (GAS), glucagen (GLU), were measured with radioim-munossay(RIA). Results Rectal resting presure (RRP) and anal sphincter resting presure (ARP) were significantly higher in the patients with diarrhea predominant type IBS(Dp-IBS)than in helthy subjects, and the MSQP was significantly lower in patients with constipation predominant type IBS (Cp-IBS) than in healthy subjects. The DSV, DUSV and MTVwere significantly lower in the patients with (Dp-IBS) than in healthy subjects, wheras FSV,DSV and DUSV were significantly higher in the patients with Cp -IBS compared with helthy subjects. The plasma levels of GAS and MTL in IBS patients were significantly higher than those in healthy subjects; plasma levels of plasma GAS and MTL in IBS patients were significantly higher than in helthy subjects, while the plasma concentration of GLU was significantly lower in patients with Dp-IBS and significantly higher in the patients with Cp-IBS when comparedwith healthy subjects; ARP and MSQP were positively correlated with plasma MTL in patients with IBS; DSV and MTV were negatively correlated with the plasma GLU in the patients. Conclusions Anorectal pressure and gastrointestinal hormones were abnormal in patients with IBS. Anorectal pressuer was positively correlated with concentration of gastrointestinal hormones in plasma.