Clinical value of the combined detection of serum CEA, CA199, CA242, and CA724 in colorectal cancers

Objective To explore the significance of serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199, CA242, and CA724 combined detection in the diagnosis of colorectal cancer. Methods The levels of CA724, CA242, CA199, and CEA in 112 cases of colorectal cancers, 74 cases of colorectal benign lesion group, and 128 cases of healthy physical examination group were detected by chemiluminescence method. Results The levels of CEA, CA199, CA242, and CA724 in sera were significantly higher than those in colorectal cancer group (P 0.05). In the clinical diagnosis of colon and rectal cancers, the sensitivity, specificity, and detection rate of CEA were 52.3%, 93.5%, and 76.8%; CA199 was 46.9%, 91.9%, and 73.6%; CA242 was 56.3%, 94.6%, and 79.0%; and CA724 was 49.2%, 93.0%, and 75.2%. The combined detection of CEA, CA199, CA242, and CA724 were 76.6%, 96.2%, and 87.6%. Conclusions In the diagnosis of colorectal cancer, combined detection of serum CEA, CA199, CA242, and CA724 has more clinical value than single detection, and can improve the diagnostic sensitivity and detection rate. Key words: Carcinoembryonic antigen/ME; CA-19-9 antigen/ME; Antigens, tumor-associated, carbohydrate/ME; Colorectal neoplasms/ME