2014•Int J Radiat Med Nuel MedRequires access
Advances on humanized monoclonal antibody technology
涂少华, 陶嵘, 沈江帆
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Abstract
With the development of molecular biology, people can humanize mouse monoclonal antibody with DNA recombination, antibody library and transgenic technology which developed antibody techniques from chimeric and grafted antibody to fully human antibody. The humanized monoclonal anti-bodies overcome the clinical shortage of mouse monoclonal antibody from different angles, also bring a new dawn to the diagnosis and treatment of human disease. This article will summarize the progress on the hu-manization of mouse monoclonal antibody.
Key words:
Antibodies,monoclonal; Phage display; Humanized antibody; Chimeric antibody; Complementarity-determining region grafted antibody; Fully human antibody