2012•China Animal Husbandry & Veterinary MedicineRequires access
Research Progress in Monoclonal Antibodies
Huang Yin-jun
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Abstract
Hybridization techniques have made mouse monoclonal antibody widely use in diagnosis and research of human disease,and established the first milestone of therapeutic antibody.With the biology development and antibody genetic structure clarification,people can humanize mouse antibody with DNA recombination and antibody library which developed antibody techniques from chimeric and reshaped to human antibody.Both humanized monoclonal antibody and its derivative overcome the clinical shortage of mouse antibody from different angles,also bring a new dawn to made antibody.