Research and Development of Monoclonal Antibody Drugs

Hybridoma technique has made mouse monoclonal antibody. With the recombinant DNA technology and antibody library technology,people have modified mouse monoclonal antibody to overcome its clinical application defects,developed human-mouse chimeric antibody and humanized antibody and full human antibody. Because of good specificity and significant effects,monoclonal antibody drugs become a research hotspot of biopharmaceutical companies. With the development of biotechnology,a variety of monoclonal antibody derivatives are generated,including antibody-drug conjugates,small molecular antibodies and bispecific antibodies. In this article,the history,progress and prospect of therapeutic antibodies are reviewed.