2012•Guoji zhongliuxue zazhiRequires access

DNA methylation and gastric cancer

Jun Peng Luo, Zhi‐Qiang Ling

Abstract

Abnormal methylation of the tumor-related genes is frequently found in the development of gastric cancer.Cancer cells exhibit two opposing methylation abnormalities:genome-wide hypomethylation and certain tumor suppressor gene hypermethylation.Furthermore,it seems that the level of DNA methylation is closely associated with the prognosis of gastric cancer.Recently,a great deal of research has been conducted to reveal the corelation of DNA methylation and gastric cancer. Key words: Stomach neoplasms; DNA methylation; Gene expression

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Key concepts: DNA methylation, Methylation, Cancer, Biology, Cancer research, Gene, DNA, RNA-Directed DNA Methylation