Latest research of DNA methylation in gastric carcinoma

Gastric tumorigenesis is a complicated process involved a lot of steps and aberrant genes. Until now , DNA methylation as an epigcretic modification way has conducted as a focus in gastric carcinoma research. Aberrant DNA methylation reinforce the gastrical tumorigenesis by promoting gene mutation and enhancing the chromatosome instability ,etc. With the development of DNA methylation research, the technology detecting the situation of DNA methylation also made some progress and it had widely used in gastric cancer research. In addition, gene promoter methylation has been acted as an important tumor marker in diagnosis of stomach cancer and the agent for regulation DNA methylation have also been used in treatment of gastric carcinoma.