Progress in the Study of Correlation between DNA Methylation and Gastric Cancer

DNA methylation is one of the major ways of epigenetic modulation and it plays a critical role in the regulation of gene expression. Tumor tissue generally has aberration of DNA methylation, including hypomethylation of oncogene and hypermethylation of tumor suppressor gene, which are closely related with the cell proliferative cycle. Recent studies have demonstrated that methylation of gastric cancer-associated gene has close correlation with the genesis of gastric cancer, and has the potential value of being the molecular marker for the diagnosis of gastric cancer and the target of gene therapy.