Research of relationship between type of human papilloma virus infection and risk of cervical cancer

Objective To analyze the association between types of human papilloma virus (HPV) infection and risk of cervical cancer. Methods A retrospective study was conducted from 1st January 2015 to 31st December 2015. Based on the standardized diagnosis system, thinprep cytologic test (TCT), thin layer cell HPV-DNA and colposcopy cervical tissue pathologic examination were taken in patients according to their conditions. The demographic information of patients was included to assess associations of each type of HPV infection with risk of cervical cancer. Among them, pathologic examination of vaginal microscopically cervical tissue was considered as the gold standard. Results This study included 2 195 patients. Age is one of risk factors of cervical cancer. Diagnosed low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) by using TCT test was prone to induce high level of epithelial lesions or invasion cancer. Single and multiple HPV infections in patients had no statistical difference in the risk of cervical cancer. HPV16 incidence was higher, and is a high risk factor of cervical cancer (OR= 6.27), regardless of single and multiple HPV infections. Conclusion It is necessary to take an early screening of cervical cancer for women (> 50 years). HPV16 is a high risk factor of cervical cancer. TCT and HPV screening can be used to potentially avoid early-stage cervical cancer. Key words: Cervical cancer; Thinprep cytologic test (TCT); Human papilloma virus (HPV); Pathological examination; HPV16