The effect and cost of conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children

Objective To observe effect,adverse reactions and cost of conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children.Methods In treatment group,20 children with incipient nephrotic syndrome were treated with Methylprednisolone [1.4 mg/(kg · d)] by intravenous drip adding in glucose; after negative proteinuria three times in a row,treated with oral prednisolone [2 mg/ (kg · d)].In control group,20 children with incipient nephrotic syndrome were treated with oral prednisolone [2 mg/(kg · d)].Results The time of dropsy fadeaway and proteinuria turning to negative in treatment group were shorter than those in control group [(10.25 ± 3.782)d vs.(12.85 ± 3.360)d,(14.45 ± 4.383)d vs.(18.56 ± 4.196)d].The incidence of water-sodium retention,liver damage and hospital infection in treatment group was lower than that in control group (x2 =4.329,P=0.037).Besides,cost in treatment group did not increase [(3419.99 ± 684.90) in treatment group,(3502.80 ± 376.63) in control group].Conclusion Conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children has fast and good effect,low adverse reactions,without cost increased,which is a safety and effective treatment method. Key words: Methylprednisolone;  Children;  Nephrotic syndrome;  Effect;  Cost