Effect observation of methylprednisolone shock treatment for children with steroid sensitive nephrotic syndrome

Objective To explore the clinical efficacy and safety of methylprednisolone shock treatment and traditional oral prednisone treatment on patients with steroid sensitive nephrotic.Methods 42 cases of primary nephrotic syndrome in children in our hospital from April 2010 to December 2013 were selected,and were divided into research group and control group randomly,21 patients in each group.The research group were carried out the methylprednisolone pulse therapy,the control group were carried out oral prednisone therapy enough.The urinary protein clearance time,body weight,subcutaneous fat thickness,height and bone density was recorded and compared in two groups.Results The urine protein negative time in research group was shorter than that in the control group,the difference was significant(P0.05). 3 months after treatment,body mass and subcutaneous fat thickness in control group was increased compared with before treatment(P0.05); height and bone density before and after treatment in the two groups had no significant difference(P0.05).Conclusion For the steroid sensitive nephrotic syndrome in children,methylprednisolone pulse therapy compared with oral dose prednisone can make the urine protein negative influence on faster,and children with body weight and fat less,but may in the treatment of infection and other adverse events.