A Study on gastroesophageal pH monitoring and gastrointestinal hormones in children with Hp-associated gastritis

Objective To explore the charateristics of gastrointestinal motility of Helicobacter pylori (Hp) -associated gastritis in children. Methods Serum gastrin, plasma motilin and duodenogastroesophageal reflux of 105 patients with chronic gastritis including 58 Hp-positive and 47 Hp-negative patients were studied with radioimmunoassay and gastroesophageal three pH monitoring technique. Results The level of serum gastrin in Hp-positive group was higher than that in Hp-negative group and normal control group (t = 3.326 and 3.837, both P 0.05) ; the duodenogastric reflux rate in Hp-positive patients (50%) was higher than that in Hp-negative patients (13%) (χ2 = 7.383, P < 0.01) . Conclusion Hp infetion may result in remarkable raising of serum gastrin and marked decline of plasma motilin in children with chronic gastritis. In children with Hp-associated gastritis the gastroesphageal reflux rate tended to decrease, while the duodenogastric reflux rate tended to increase. Key words: Helicobacter pylori; Gastritis; Gastrointestinal motility; Gastrointestinal hormones